Preparation of 2-heteroatom substituted 4-oxo-4-arylbutanoates via thio- and aza-Michael addition
نویسندگان
چکیده
منابع مشابه
Enantioselective synthesis of 3-substituted 1,2-oxazinanes via organocatalytic intramolecular aza-Michael addition.
A highly enantioselective intramolecular 6-exo-trig aza-Michael addition was developed to afford chiral 3-substituted 1,2-oxazinanes in high yields (up to 99% yield) and good enantioselectivities (up to 98/2 er). These reactions were enabled by a quinine-derived primary-tertiary diamine as a catalyst and pentafluoropropionic acid (PFP) as a co-catalyst.
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The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...
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The resistance of antimicrobials has become a global hazard with the irrational use of antibiotics. Infection of drug-resistance bacteria seriously threatens human health. Currently there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S,Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylfuran-2-yl) methy...
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We report on the preparation of 4-aza-5,6-dimethylbenzimidazolylcobamide and 5,6-dimethyl-7-azabenzimidazolylcobamide. These vitamin B12-analogs were required as reference compounds for comparison with a corrinoid previously isolated in small amounts for Eubacterium limosum grown in the presence of 4(5)-aminoimidazole. 4(7)-Aza-5,6-dimethylbenzimidazole was synthesized from N-1-benzyl-4-nitroim...
متن کامل2-(4-Methoxyphenyl)-4-oxo-4-phenylbutanenitrile
The title mol-ecule, C(17)H(15)NO(2), is twisted, the dihedral angle between the terminal benzene rings being 63.30 (6)°. In the crystal, C-H⋯O and C-H⋯N inter-actions lead to supra-molecular layers in the ab plane. These are connected along the c axis via C-H⋯π inter-actions.
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ژورنال
عنوان ژورنال: Journal of the Serbian Chemical Society
سال: 2012
ISSN: 0352-5139,1820-7421
DOI: 10.2298/jsc110526202l